Antinuclear Factors

Guideline

1. Found non-specifically in many autoimmume diseases including RA, scleroderma and myositis.
2. Levels > 1/160 may indicate some autoimmune process. If clinical features suggest SLE then investigate further with DNA antibody profile.

Extractable Nuclear Antigens (ENA)

• Sm: SLE
• Ro/La: SLE, Sjogrens syndrome
• Nuclear rnp (high): MCTD
• Scl 70: progressive systemic sclerosis
• Centromere: CREST
• Ribosomal ANA: RA, RA+Sjogren's

Document Information
Appraiser: Dr Kennedy
Expiry Date: 11/04/04
Author: Dr Tom Kennedy
Organisation: Arrowe Park Hospital