Intravenous Iloprost for Raynaud's

Wirral Hospital NHS Trust

Protocol for Rheumatology Daycase Patients

Dose

Iloprost 50mcg to be given by I.V. infusion on five consecutive days. (Please note this is an unlicensed product)

On Admission

1. Check that the daycase card or patient notes do not indicate that a medical review is required.
2. Obtain baseline observations of pulse, temp and BP.
3. Iloprost prescribed by medical staff on i.v. card.
4. Analgesia and anti-emetic prescribed by medical staff and administered prior to infusion commencing to help reduce side-effects of nausea and headache.

Infusion

• Iloprost 50mcg. Add to 250ml saline 0.9%.
  
• Day 1:
• Day 2: As day 1.
• Day 3: As day 1
• Day 4: Start at MAX rate tolerated and infuse over 6 hours. Observations to be checked hourly.
• Day 5: Start at MAX rate tolerated and infuse over 6 hours. Observations to be checked hourly.

Side Effects/Patient Advice

1. Facial flushing.
2. Headache
3. Nausea and vomiting
4. Tachycardia
5. Lowering or increase in blood pressure
6. Abdominal cramps

Follow Up

1. Home after 1 hour following end of infusion if well and BP and pulse satisfactory.
2. Consider keeping patient in for a few extra hours if unwell. Contact medical staff if in any doubt.
3. Arrange OPD review for 4 months if patient does not already have one arranged.

Document Information
Expiry Date: 11/04/04
Author: Richards, Sue. Sr
Organisation: Wirral Hospital Trust