Methotrexate

Name of the treatment you are taking

Methotrexate - Maxtrex

Why are you taking Methotrexate?

These tablets are used to treat Arthritis and inflammatory disease. They are thought to slow down disease activity and reduce inflammation. They do not have a direct pain relieving effect so you may need to continue with your other pain reliving tablets as directed by your doctor.

How should I take Methotrexate?

The dose is usually 7.5 mg as a single dose once a week. Swallow the tablets whole with water or milk. Remember to take the same number of tablets the doctor has told you. It is recommended you also take 5 mg Folic Acid weekly, but not on the same day as Methotrexate, usually 3 days after. This is to reduce the chances of side-effects (see below).

How long will I need to take Methotrexate?

Generally for long term at the doctor's discretion. When you have maintained a significant improvement (remission) for a suitably long period, we may decrease the dose and then stop.

How long will it take to work?

Methotrexate may take 3 months to work. Do not become discouraged if the effect is not immediate.

What do I do if I forget to take Methotrexate?

Take the missed dose immediately and then continue weekly on the same day the following week.

Can I take alcohol with Methotrexate?

This medicine may upset your liver. We therefore advise that alcohol should not be taken in conjunction with Methotrexate.

Are there any side effects from Methotrexate?

All drugs have side effects but not every one will experience them. With these tablets the following have been reported.

1. Nausea
2. Vomiting
3. Diarrhoea
4. Indigestion
5. Mouth Ulcers

Can I take other medicines with Methotrexate?

There are many drugs that interfere with Methotrexate. Be sure to inform your doctor or pharmacist of any other medication you may be taking.

Can I start a family?

Women: If you want to start a family please contact your GP with a view to changing your medication. It is advisable to discontinue the tablets 6 months before becoming pregnant.
Men: These tablets may lower your sperm count, but this is reversible on stopping the tablets.

Your responsibility?

It is your responsibility to visit your GP for regular blood tests.

The usual recommendation is weekly for 4 weeks and then monthly. This is for your own protection as these tablets may affect your blood count.

What else do I need to know?

1. Never allow yourself to run out of tablets.
2. Always take your treatment as instructed.
3. If you no longer require your tablets take them to your pharmacist who will dispose of them.
4. Always keep medicines out of the reach of children.
5. Never give your tablets to other people. This treatment is especially for you.
6. Monitoring the effects of these tablets is important. This includes blood tests.

Wirral Hospital NHS Trust
Rheumatology Services
Dr T D Kennedy - Consultant Rheumatologist
Dr E George - Consultant Rheumatologist

Any further queries please telephone:
Specialist Nurses Rheumatology
Direct Telephone Number: 0151 604 7195

Clinical Services Pharmacist
Tel No: 678 5111, ext 2445

Document Information
Expiry Date: 11/04/04
Author: Richards, Sue. Sr
Organisation: Wirral Hospital Trust