Remicade

Wirral Hospital NHS Trust
Rheumatology Department

Why am I being treated with Remicade?

Remicade (infliximab) is a new type of medication that has recently become available for the treatment of Rheumatoid Arthritis. When given in combination with Methotrexate, this medication has been proven to greatly reduce the signs and symptoms of Rheumatoid Arthritis.

When will I start to see the benefit of Remicade?

Remicade works rapidly - many of the patients that have received it have seen a substantial improvement in as little as two weeks.

How does Remicade work?

In Rheumatoid Arthritis your immune systems over responds, which results in inflammation, causing, for example, swollen and tender joints. A substance called TNF plays a major part in the inflammatory process. Remicade neutralises the TNF, thus helping to reduce the inflammation.

How is it given?

Remicade is given as an intravenous (IV) infusion. The infusion involves inserting a small narrow needle (called a venflon) into your arm, through which the Remicade is infused. The treatment is given over a 2-hour period. Patients will be required to remain under observation for a further 2 hours.

How often will I have the infusion?

Initial doses (infusions) are given at weeks 0 (the day you start), 2 and 6, and then at 8-weekly intervals.

Will I have a reaction to the infusion?

During the infusion some people notice a mild reaction, such as itching or a stinging sensation in the skin. Although rare, other types of reaction have been observed and these include chills, wheeziness, difficulty in breathing or low blood pressure. If you experience any kind of discomfort during the infusion, let the nurse know immediately. The nurse may simply slow down, or temporarily stop, the infusion. Reactions are generally resolved quickly. If you have any of these reactions, your Rheumatologist may give you a paracetamol or an antihistamine to resolve the reaction.

What are the most common side effects?

The most common side effects include upper respiratory tract infections, headache, nausea, coughing and diarrhoea.

What if I develop a serious infection?

If you develop a serious infection, therapy with Remicade will be stopped. If you have a chronic infection, or a history of recurring infection, be sure to let your doctor know. Also, tell your doctor if you develop an infection whilst receiving Remicade. If you experience any side effects as a result of receiving Remicade, please contact your Rheumatology Department/Helpline.

Can I drive after the infusion of Remicade?

Yes. The infusion is not sedating at all and you will be able to continue with our normal schedule. Their doctor will advise patients who need an antihistamine, which can be sedating, whether or not they can drive.

Do I need any special checks while I am being treated with Remicade and Methotrexate?

As you will already have been treated or are being treated with Methotrexate, you will already be having regular blood checks. It is important that this is continued.

Can I take other medicines while I am being treated with Remicade and Methotrexate?

Some drugs interact with Methotrexate, whilst little is known about possible drug interactions with Remicade and other drugs. Therefore it is important that you always let any doctor treating you, know that you are receiving Remicade and Methotrexate.

Does Remicade afect pregnancy?

You should not become pregnant whilst receiving Remicade.

May I drink alcohol whilst receiving Remicade and Methotrexate?

It is recommended that you stick within the national guidelines for alcohol consumption.
It is important for you to discuss any questions or concerns you have about Remicade, or your treatment, with the Rheumatology Team. Do not be embarrassed or afraid to mention something that you have a question about. The Rheumatologists are happy to provide honest answers to your questions and know that you want and need to be well informed about your disease.

Any further queries please telephone:
Specialist Nurses Rheumatology
Direct Telephone Number: 0151 604 7195

Clinical Services Pharmacist
Tel No: 678 5111, ext 2445

Document Information
Expiry Date: 11/04/04
Author: Richards, Sue. Sr
Organisation: Wirral Hospital Trust